首页期刊介绍全国理事会投稿须知新闻动态期刊目录广告征订留言板联系我们编辑的话
  您当前的位置:首页 >> 正文

高浓度细颗粒物暴露职业人群血清克拉拉细胞蛋白与肺功能相关性研究 [中文引用][英文引用]

Association of Serum Clara Cell Protein with Pulmonary Function in Occupational Populations with High-PM2.5 Exposure

作者(英文):YU Haitao1  WANG Ting2  WANG Yanhua2  XU Mengmeng2  WANG Zhenjie2  WU Nan2  ZHAO Hongwei1  DAI Yufei2  DUAN Huawei2 
单位(英文): 
关键词(英文):particulate matter  CC16  pulmonary function 
分类号:R114
出版年·卷·期(页码):2019·9·第5期(418-424)
DOI:
-----摘要:-------------------------------------------------------------------------------------------

目的 在高浓度细颗粒物(Fine particulate matterPM2.5)暴露职业人群中,探讨血清克拉拉细胞蛋白(Clara cell proteinCC16)水平与肺功能变化之间的关系。方法 选取390名男性焦炉工人作为暴露组,其中低PM2.5215人、高PM2.5175人,同地区的对照组工人115名。酶联免疫吸附测定法(ELISA)检测血清中CC16水平,使用便携式电子肺活量计测量研究对象肺功能的改变。结果 3组人群血清CC16水平随PM2.5暴露水平的增加呈下降趋势,且差异具有统计学意义(P=0.019)。研究发现FEV1/FVC与血清CC16水平之间具有正相关关系(r=0.094P=0.035)。简单线性回归校正年龄、身高、体重、饮酒和吸烟,亦发现在全人群中FEV1/FVC随血清CC16降低而降低(P=0.045)。在非吸烟人群中,FEF25%~75%%FEV1/FVC与血清CC16水平之间具有正相关关系,但在吸烟人群中,各项肺功能指标与血清CC16水平之间均无线性相关关系。年龄分层后发现,在年龄≤ 36岁的人群中,FEF25%~75%%FEV1%FEV1/FVC随血清CC16的降低而降低(P分别为0.0320.0360.029),但在年龄> 36岁的人群中,并未发现各项肺功能指标与血清CC16显著关联。结论 高浓度PM2.5暴露职业人群血清CC16水平与肺功能降低之间存在明显的相关性,血清CC16水平改变可以作为高浓度PM2.5暴露致肺损伤的效应标志物。

-----英文摘要:---------------------------------------------------------------------------------------

Objectives The aim was to investigate the association of serum clara cell protein (CC16) and pulmonary function in occupational populations with high fine particulate matter (PM2.5) exposure. Methods We selected 390 male coke oven workers as the exposure group, of whom 215 workers in low-PM2.5group and 175 workers in high-PM2.5 group, then selected 115 non exposed workers as the control group. Enzyme-linked immunosorbent assay (ELISA) method was used to detected the serum CC16 levels, and the pulmonary function was measured by spirometer. Results With the increase of PM2.5 exposure level, serum CC16 levels reduced (P=0.019). There was a positive correlation between FEV1/FVC and serum CC16 levels (r=0.094, P=0.035). There also was a positive correlation between FEV1/FVC and serum CC16 levels (P=0.045) in total population after simple linear regression adjusted age, height, weight, drinking and smoking. After stratification by smoking, the subjects showed a positive correlation between FEF25%~75%%, FEV1/FVC and serum CC16 levels in non-smokers. However, there was no any correlation between lung function and serum CC16 levels among the smokers. After age stratification, the authors found a positive correlation between FEF25%~75%%, FEV1%, FEV1/FVC and serum CC16 levels in population younger than 36 years (P values were 0.032, 0.036 and 0.029, respectively). However, the authors did not find similar correlation among population who is older than 36 years. Conclusions There is significant correlation between serum CC16 level and lung function in population with high PM2.5 exposure. The decrease of serum CC16 levels could be used as a marker for lung injury caused by high-PM2.5 exposure.

-----参考文献:---------------------------------------------------------------------------------------

欢迎阅读《环境卫生学杂志》!您是该文第 401 位读者!

若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式: 于海涛1,,王婷2,,王艳华2,,许梦梦2,,王振杰2,,吴难2,,赵红伟1,,戴宇飞2,,段化伟2.高浓度细颗粒物暴露职业人群血清克拉拉细胞蛋白与肺功能相关性研究.环境卫生学杂志.2019;9(5):418-424.
英文著录格式: YU,Haitao1,,WANG,Ting2,,WANG,Yanhua2,,XU,Mengmeng2,,WANG,Zhenjie2,,WU,Nan2,,ZHAO,Hongwei1,,DAI,Yufei2,,DUAN,Huawei2.Association of Serum Clara Cell Protein with Pulmonary Function in Occupational Populations with High-PM2.5 Exposure..2019;9(5):418-424.

与该文相关的文章(仅限于本刊内

已投本刊未发表相似文章

《环境卫生学杂志》编辑部 © 2014
  ICP备案号:京ICP备11024750号     京公安备案:11010202007828号