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孕产妇尿中1-羟基芘水平与孕产妇及新生儿hOGG1和XRCC1基因多态性的研究 [中文引用][英文引用]

Study on the Level of Maternal Urinary 1-Hydroxypyrene and the Polymorphism of Maternal and Neonatal hOGG1 and XRCC1 Genes

作者(英文):ALIMASI Ayixiemuguli  MAIMAITI Erxiding  LU Ying  ZHAO Tingting 
单位(英文): 
关键词(英文):1-OH-P  XRCC1  hOGG1 
分类号:R114
出版年·卷·期(页码):2019·9·第5期(425-429)
DOI:
-----摘要:-------------------------------------------------------------------------------------------

目的 探讨乌鲁木齐市孕产妇多环芳烃(polyeyclic aromatic hydrocarbonsPAHs)暴露与孕产妇及新生儿hOGG1XRCC1基因多态性之间的关系。方法 采集乌鲁木齐市某家医院115位孕产妇尿液、静脉血及新生儿脐带血,采用聚合酶链反应限制性片段长度多态性分析(PCR-RFLP)孕产妇与新生儿的hOGG1XRCC1的基因位点多态性,采用酶水解液相色谱质谱联用仪检测孕产妇尿中PAHs内暴露标志物1-羟基芘(1-OH-P)。结果 孕产妇尿中1-OH-P浓度为0.3400.208~0.555μg/mmol Cr。孕产妇hOGG1326Ser/Cys基因型不同,体内1-OH-P的浓度也不同(P<0.05)。携带不同的XRCC1399Arg/Gln基因型新生儿,其母亲体内1-OH-P的浓度存在统计学差异(P<0.05)。携带不同XRCC1399Arg/Gln基因型的孕产妇,其体内的1-OH-P的浓度差别无统计学意义(P>0.05)。携带不同的hOGG1326Ser/Cys基因型的新生儿,其母亲的体内1-OH-P的浓度无统计学差异(P>0.05)。结论 与国内相关研究相比,乌鲁木齐市孕产妇体内的PAHs处于高暴露水平。携带hOGG1326Ser/Cys基因的孕产妇机体在PAHs高暴露环境中DNA损伤更加敏感。

-----英文摘要:---------------------------------------------------------------------------------------

Objectives To investigate the relationship between maternal polycyclic aromatic hydrocarbon(PAHs) exposure in Urumqi and the polymorphisms of maternal and neonatal hOGG1 and XRCC1 genes. Methods A total of 115 maternal urine, venous blood and neonatal cord blood were collected from a hospital in Urumqi, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for gene locus polymorphism of maternal and neonatal hOGG1 and XRCC1. The use of enzymatic hydrolysis-liquid chromatography-mass spectrometry to detect internal exposure marker of PAHs,1-OH-P, in the maternal urine. Results The median level of 1-OH-Pconcentration in maternal urine was 0.340 (0.208~0.555) μg/mmol Cr. The maternal hOGG1326Ser/Cys genotype was different, and the concentration of 1-OH-Pin the body was also different (P<0.05). There was a statistically significant difference in the concentrations of 1-OH-P in the mothers with neonates carrying different XRCC1399Arg/Gln genotypes(P<0.05). There was no significant difference in the concentration of 1-OH-P between the parturient carrying different XRCC1399Arg/Gln genotypes (P>0.05). There was no significant difference in the concentration of 1-OH-Pin the mothers with neotates carrying different hOGG1326Ser/Cys genotypes (P>0.05). Conclusions Compared with domestic related research, PAHs in parturient in Urumqi were at a high the exposure levels. Maternal bodies carrying the hOGG1326Ser/Cys gene are more susceptible to DNA damage in the high exposure environment of PAHs.

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中文著录格式: 阿依谢姆古丽·阿力马斯,,尔西丁·买买提,,鲁英,,赵婷婷.孕产妇尿中1-羟基芘水平与孕产妇及新生儿hOGG1和XRCC1基因多态性的研究.环境卫生学杂志.2019;9(5):425-429.
英文著录格式: ALIMASI,Ayixiemuguli,,MAIMAITI,Erxiding,,LU,Ying,,ZHAO,Tingting.Study on the Level of Maternal Urinary 1-Hydroxypyrene and the Polymorphism of Maternal and Neonatal hOGG1 and XRCC1 Genes..2019;9(5):425-429.

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