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孕期多环芳烃暴露对子代脑源性神经营养因子影响 [中文引用][英文引用]

Effects of Polycyclic Aromatic Hydrocarbons Exposure during Pregnancy on Progeny Brain-derived Neurotrophic Factors

作者(英文):ALEMUJIANG Xiahaida  MAIMAITI Erxiding  LU Ying 
单位(英文): 
分类号:R114
出版年·卷·期(页码):2019·9·第5期(430-434)
DOI:
-----摘要:-------------------------------------------------------------------------------------------

目的 本研究通过对多环芳烃(PAHs)暴露的产妇进行新生儿脑源性神经营养因子(BDNF)、芳香烃受体(Ahr)和孕妇Ahr浓度的检测,比较孕早期、孕中晚期及孕早中晚全期产妇PAHs暴露对子代BDNF的影响。方法 选取孕早期、孕中晚期及孕全期PAHs暴露的产妇115名,采用酶联免疫吸附法(ELISA)对新生儿BDNFAhr和产妇Ahr浓度进行检测,并对三组实验室检查结果分别两两进行统计学分析。结果 孕早期与孕中晚期PAHs暴露两组新生儿BDNF和产妇Ahr浓度相比较无统计学差异(Z分别为-1.799-1.360P>0.05),新生儿Ahr相比较有统计学差异(Z=-3.052P<0.01)。孕早期与孕全期PAHs暴露两组新生儿BDNFAhr和产妇Ahr浓度相比较有统计学差异(Z分别为-3.300-3.614-1.360P<0.01)。孕中晚期与孕全期PAHs暴露两组新生儿BDNFAhr和产妇Ahr浓度相比较无统计学差异(Z分别为-0.800-0.540-0.485P>0.05)。新生儿BDNF水平与新生儿Ahr、产妇Ahr的相关性分析结果显示无统计学意义(rs分别为-0.013-0.062P>0.05)。结论 孕早期PAHs暴露对新生儿BDNF的影响较大;PAHs暴露的产妇及新生儿在孕早期更容易吸收PAHs

-----英文摘要:---------------------------------------------------------------------------------------

Objectives This study was performed to detect the brain-derived neurotrophic factor(BDNF) and aromatic hydrocarbon receptor (Ahr) levels of neonates and Ahr levels of pregnant women with PAHs exposure during pregnancy, and to compare the effects of maternal PAHs exposure on the offspring of BDNF in the early pregnancy, middle, late and whole pregnancies. Methods 115 parturients with PAHs exposure during early, middle, late and whole pregnancies were selected. enzyme-linked immunosorbent assay(ELISA) method was used to detect the concentrations of Ahr and BDNF of neonatesas well as Ahr of parturients. Three groups of test result were statistically analyzed in pairs. Results There was no significant difference (Z values were -1.799 and -1.360, vespectively, P>0.05) in BDNF of neonates and Ahr of parturient between the early, middle and late pregnancy exposures to the PAHs. There were statistically significant differences (Z=-3.052, P<0.01) in Ahr of neonates. There were statistically significant differences (Z values were -3.300, -3.614 and -1.360, respectively, P<0.01) in BDNF and Ahr of neonates and Ahr of parturients between the early, middle and late pregnancies. There were no statistically significant differences (Z values were -0.800, -0.540 and -0.485, respectively P>0.05) in BDNF and Ahr of neonates and Ahr of parturients between the middle, late and whole pregnancies. The correlation analysis between BDNF and Ahr of neonates or between BDNF of neonates and Ahr of parturients showed no statistical significance (rs=-0.013, -0.062, P>0.05). Conclusions The effect of PAHs exposure on BDNF of neonates in early pregnancy is greater. PAHs exposed parturients and neonates more easily absorbed PAHs in the early pregnancy.

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中文著录格式: 夏海达·阿勒木江,,尔西丁·买买提,,鲁英.孕期多环芳烃暴露对子代脑源性神经营养因子影响.环境卫生学杂志.2019;9(5):430-434.
英文著录格式: ALEMUJIANG,Xiahaida,,MAIMAITI,Erxiding,,LU,Ying.Effects of Polycyclic Aromatic Hydrocarbons Exposure during Pregnancy on Progeny Brain-derived Neurotrophic Factors..2019;9(5):430-434.

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